Endocrine Abstracts

Hypogonadotropic hypogonadism as a part of hypopituitarism can be a cause of persistent amenorrhea and hypoestrogenemia in women of reproductive age as it is observed in postmenopause. We know that premature and early menopause leads to accelerated aging with such markers as decreased quality of life, phyco-emotional deprivation, dyslipidemia, bone mineral density and others. We hypothesized that untreated hypogonadism in young women with hypopituitarism could cause premature ...

Central hypogonadism (CH) is a syndrome that can be revealed in women with hypoestrogenic amenorrhea due to the lack of normal response of gonadotropins to the hypoestrogenemia. CH can be caused by organic lesion of the hypothalamo-pituitary region or has idiopathic character – without any structural background. This syndrome is often called ’hypogonadotropic hypogonadism’, but LH and FSH levels within ’normal’ laboratory range does not exclude CH beca...

Central hypogonadism (CH) is a syndrome that can be diagnosed in women with hypoestrogenic amenorrhea and a lack of normal response of gonadotropins to hypoestrogenemia in the absence of other reasons. To date, about 50 genes were reported as a possible reason for this condition, but the genetic basis is still unknown for approximately a half of CH cases.Patients and Methods: Some of the CH-related genes are expressing in leukocytes of peripheral blood: ...

Hypogonadotropic hypogonadism is a syndrome which may be manifested clinically by low sex steroids because of low (or inappropriately normal) gonadotropins. To date, more than 30 genes were reported as possible reason for this condition, but genetic basis is still unknown for ~60% of HH cases. Due to this fact we decided to analyze mRNA expression of several HH-related genes which can be found in leukocytes of peripheral blood: GNRHR and GNRH1 (which are necessary for adequate...